Hypoglycemic Effect of Extracts from Diabetic KK - AY Mice Lagerstroemia speciosa L . Leayes inGenetically

The hypog]ycemic etfects of Lagerstroemia speciosa L., known by the Taga]og name of banaba in the Phi]tipines, were studied using hereditary diabetic mice (Type II, KK-AYfTa Jcl). The mice were fed a test diet containing 5ei3 of the hot-water extract (HWE) from banaha leaves, 3% of the water e]uent of the partial fraction unadsorbed onto HP-20 resin ef HWE (HPWE), and 2% of the methanot etuent ef the partial fraction adsorbed onto HP-20 Tesin of it (HPME) for a feeding period of 5weeks. The elevation of blood plasma glucose level in non-insulin dependent diabetic mice fed the cellu]ose as centro] (CEL) diet were almost entirely suppressed by addition of either HWE or HPME in place of cellu]ose in the CEL diet. Water intakes were inclined to increase graduat]y in the gToup fet1 either CEL or HPWE, but lower in the mice fed either HWE or HPME than in the animals giyen either CEL or HPME. The level of serum insulin and the amount of urinary excreted glllcose were also lowered in mice fed HWE. Plasma tota]